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Safety and Monitoring - Always start with a low dose to assess tolerance

Further experimental and longitudinal studies are needed to clarify these mechanisms

Given the importance of GH and GH-IGF-1-IGFBP-3 axis in controlling body height [2, 3, 4], this study for the first time used the GH-IGF-1-IGFBP-3 axis of short-stature children for exercise intervention to clarify the effect of exercise on this growth axis